Drug Response - Depression Panel
Depression Panel
The forms of CYP2D6 & CYP2C19 that you inherited are reported, along with your level of enzyme activity to process certain drugs -- either ultrarapid, extensive, intermediate or poor.
An extensive battery of CYP2D6 & CYP2C19 polymorphisms is evaluated. Buccal swabs ... blood not required. 10-day standard turnaround time.
Insurance and health savings accounts may cover this test. CPT codes 83891x1, 83900x1, 83914x14, 83812x1.
Many commonly used medicines taken to treat depression require active forms of liver enzymes CYP2D6 and CYP2C19 in order to be safe and effective
Depression is a common condition, treatable with available medications. However, a third of patients do not respond to treatment. One reason is that the medication is not activated by needed liver enzymes when nonfunctional or reduced activity forms are inherited. For example, the entire CYP2D6 gene is sometimes missing. Alternatively, the standard dose is too low for persons who have multiple copies of the CYP2D6 gene, or especially active forms of the CYP2C19 gene.
Other patients have unexpected adverse events associated with being unable to eliminate the drug at a normal rate.
Your level of activity for these genes is determined by the forms of these enzymes inherited from your parents. Unlike many lab tests, this information only has to be tested once! It does not change over time, and is relevant to a long list of medications.
This information is expected to be very useful in selecting medicines likely to be safe and effective for you, and in adjusting drug dosage. Examples of how clinical outcomes vary according to the level of CYP2D6 & CYP2C19 activity are given here. No claim is made that all aspects of CYP2D6 or CYP2C19 metabolism are investigated. Discuss this information with your physician.